The College of Arts and Sciences began in July 1945 as the College of Liberal Arts of the Manila Central University. In the Following year it assumed a new and distinct department as the Allied Colleges, with the Colleges of Education and Normal.

In the years that followed, the College of Arts and Sciences was separated from the College of Education.

The succession of leadership commenced in 1947 with Dr. Eugenia Rens-Benchler who was followed by Atty. Jose Santos in the mid-70’s. In 80’s until the millennium, Dean Amanda Lorenzana held the post.

Until 1985 when the College of Arts and Sciences was transferred to the FDT Building in the Caloocan campus, the College has been hound for the last 40 years in the Mayhaligue building.

During the incumbency of Dean Lorenzana, the 3rd CAS Dean, the College of Arts and Sciences was granted Level II Accredited status by the PACUCOA.

Three years later, 1989, it acquired Level II status.

Community extension service rendered by the graduating Bachelor of Science in Biology students began in 1991-1992 in Sapang Palay.

In the same year, the Annual Bioresearch contest formally began, with Prof. Nieves Capili as the bioresearch adviser.

In 1992, the College of Arts and Sciences passed the first Reaccreditation, Level II.

In the following year, the General Education Program was conceived, with its four academic area chairpersons heading the: Humanities and Languages, the Natural Sciences, the Mathematics, and the Social Sciences Departments.

The College of Arts and Sciences celebrated its Golden Anniversary in 1995-1996.

A new curricular offering, the Bachelor of Arts in Psychology began in 1996.

The year that followed, 1997 was when the CAS formally got involved in the University Community Extension Programs and Services (UNICEPS). The College focused on literacy program for children. This same year, the CAS passed the second Reaccreditations, Level II status, from 2003 to the present. Dean Maria Lourdes P. Floresta assumes office while at the same time handles the General Education centralization in terms of instruction by:

• Conducting common examinations in many GE disciplines.
• Adopting the use of common textbook and syllabi.
• Careful faculty recruitment.
• Appropriate faculty loading according to major field of specialization.

The CAS passed the Third, Level II Reaccreditations this year. Currently, the College is immersed in curriculum revision of the BS Biology program, as well as the BS Psychology curriculum, now offered.